Cannabigerolic acid, or CBGA, is the acidic form of the cannabinoid CBG (cannabigerol). It is naturally formed inside cannabis and hemp plants when olivetolic acid and geranyl diphosphate interact and synthesize CBGA inside the trichome’s resin gland.
Although research around consumption and medicinal potential of CBGA is still in its infancy, the compound has been known by scientists for over 50 years.
Israeli researchers were the first to isolate CBG (Cannabigerol) from the plant extract. Then, 30 years later, scientists in Japan revealed that CBGA was the precursor to CBG.
CBGA isolate has many emerging pharmacological properties, ranging from its use as an anticonvulsant for Dravet syndrome (a form of epilepsy), to its anticancer potential.
To better understand CBGA’s full range of benefits and how it relates to other cannabinoids, we first must look at how and why it exists.
Many of the popular minor cannabinoids on the market are produced via chemical synthesis, whereas CBGA can be found naturally in the plant’s resin. CBGA is made inside of the plant’s resin glands, also known as trichomes.
Its primary biological function is triggering targeted plant cells into necrosis. This results in a natural leaf pruning effect, causing leaves to drop when they are no longer necessary below the canopy of the plant.
Losing these unneeded leaves can help support the plant in directing most of its energy toward producing flowers.
When CBGA is produced in the cannabis plant, it is synthesized through an enzymatic reaction (also known as geranylpyrophosphate:olivatolate geranyltransferase).
Olivetolic acid and geranyl diphosphate interact and convert to CBGA via alkylation. CBGA is the precursor to CBG (Cannabigerol) and many other active compounds found in cannabis resin.
Beyond flower production and protective functions, CBGA also performs a key role in the development of other cannabinoids.
CBGA when impacted by heat, UVB, and other phytochemicals can react and produce other major cannabinoids such as THCA, CBDA, and CBCA.
All of these compounds eventually become the active ingredients found in many hemp and cannabis products, CBD, CBC, and THC.
Though there is still a considerable amount of research that must be conducted to draw definitive conclusions around the medical benefits of CBGA, early studies suggest that CBGA may have a number of medical uses in the future.
Diabetes, especially in older patients can often come with some complex comorbidities that make managing health can become a major challenge. It is possible that CBGA isolate may help diabetic patients combat some of these complications, including comorbidities like cardiovascular disease.
CBGA has the ability to inhibit the enzyme aldose reductase. Overproduction of this enzyme is the primary contributing factor of oxidative stress, which can lead to poor heart health and other health complications.
CBGA was examined for this enzyme inhibiting property. The results in this study were highly dose dependent, and specifically showed differences in results between synthetic and plant-derived CBGA.
It was found that the synthetic forms of CBGA medications came with severe side effects for many patients. Naturally derived CBGA was a much more promising option, as it was effective and patients responded well to this treatment.
Similar to how CBGA can impact enzyme metabolizing within the body, it also has been shown to play a key role in metabolic regulation that could be vital for therapeutic use for individuals suffering from metabolic disorders.
A computer simulation was conducted in 2019 that explored CBGA’s role in activated peroxisome proliferator activated receptors (PPARs).
These are part of the nervous system that is responsible for regulating metabolism. PPARs are critical for maintaining your health, as they process lipids and reduce excess lipid accumulation.
This kind of buildup is common in metabolic diseases like diabetes, high cholesterol, or dyslipidemia. CBGA helps stimulate the PPAR receptors, further stimulating lipid metabolism avoiding excess lipids in the system.
Colorectal cancer is the third most common cancer and fourth leading cause of cancer-related death. Although there are many challenges to face in cancer therapeutics, CBGA may actually offer a promising solution in the fight against cancer.
When considering CBGA as an anti-cancer treatment we look at its cytotoxic effects. Researchers found that CGBA and other cannabinoid compounds interact synergistically for cytotoxic activity against colon cancer cell cycle arrest, apoptotic cell death, and distinct gene expression of the cancer cells.
They further explored the possibility that CBGA may also prevent the growth and proliferation of polyps, aiding as a preventive care for future carcinomas.
In more recent times, researchers have been looking to natural remedies that may be beneficial in the fight against COVID-19.
In an analysis by the University of Rhode Island, it was found that CBGA had incredibly high 3C-like protease inhibitor activity against COVID-19, more so than other phytocannabinoids.
Later in 2022, researchers began pre-clinical studies from the Oregon State University and Oregon Health and Science University on cannabinoids and SARS-CoV-2.
It was found that CBGA was able to block infection in multiple reference strains. This study has yet to be replicated in animal models or clinical trials. Though, in their findings CBGA was the only cannabinoid capable of both orthosteric binding and allosteric binding.
This could make CBGA Isolate a viable compound to suppress multiple strains of SARS-CoV-2.
More clinical trials are necessary before any of these claims can be confirmed and prescribed by a doctor. It is always best to consult a medical professional before seeking cannabinoid or hemp products for treating any illness or disease.
This safe, non-intoxicating cannabinoid is already available on the market in edible, capsule, and raw oil forms. CBGA will often have similar physical effects to CBD or other non-psychoactive cannabinoids.
CBGA has become increasingly popular as an immune system support supplement as it plays such a key role in activating the metabolism and supporting healthy nervous system functions.
This could be a great ingredient to add into tinctures, edibles, and sublingual products as it will work synergistically with CBD and other minor cannabinoids.
We get a lot of questions about our CBGA Isolate, so below we’ll do our best to answer the most common questions you might have.
Yes our isolate is 100% THC free and is ready to be used in your products regardless of what state you’re in. We can provide test results by request.
The minimum order for our CBGA Isolate is a single kilo. We do offer discounts with higher volumes and we can handle orders of hundreds of kilograms per month. Contact us via phone or email to get our bulk pricing.
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